Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway.
Gallo M, Park D, Riddle DL
Mech Ageing Dev (2011) 132: 515-8.
Category: aging, bioenergetics, mitochondria, mitochondria-transport, oxidative stress ¤ Added: Oct 13, 2011 ¤ Rating: ◊◊
The Caenorhabditis elegans misc-1 gene encodes a mitochondrial carrier with a role in oxidative stress response. The knock-out mutant has no lifespan phenotype and fails to upregulate the gei-7-mediated glyoxylate shunt, an extra-mitochondrial pathway of energy production. We show that gei-7 is required for the longevity of the mitochondrial mutant clk-1. Our data suggest that only mitochondrial mutants that upregulate gei-7 can achieve longevity.