|HSP90 manages the ends.|
Dezwaan DC, Freeman BC
Trends Biochem Sci (2010): in press.
Category: chaperone, telomere ¤ Added: Mar 21, 2010 ¤ Rating: ◊◊
The telomere environment requires an efficient means to assemble and disassemble a multitude of structures to operate correctly and to help achieve cellular homeostasis. Telomeres are challenged by a common binding specificity displayed by many of the protein components for telomeric DNA, which could result in competitive DNA interactions, and by a cell cycle-restricted timing of events, which enforces a narrow working period in which to perform numerous tasks. In this review, we discuss how the HSP90 molecular chaperone network avoids these obstacles and facilitates an effective operation of the telomere system.