Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics.
Pizzo P, Pozzan T
Trends Cell Biol (2007) 17: 511-7.
Category: calcium, cell signaling, endoplasmic reticulum, mitochondria ¤ Added: Nov 09, 2009 ¤ Rating: ◊◊
Mitochondria and endoplasmic reticulum (ER) have different roles in living cells but they interact both physically and functionally. A key aspect of the mitochondria-ER relationship is the modulation of Ca(2+) signaling during cell activation, which thus affects a variety of physiological processes. We focus here on the molecular aspects that control the dynamics of the organelle-organelle interaction and their relationship with Ca(2+) signals, also discussing the consequences that these phenomena have, not only for cell physiology but also in the control of cell death.
Keywords: Animals / Apoptosis / Calcium Signaling / Endoplasmic Reticulum / Humans / Intracellular Signaling Peptides and Proteins / Mitochondria / Mitochondrial Membranes / Mitochondrial Proteins / Necrosis