Structure casts light on mtDNA replication.
Falkenberg M, Larsson NG
Cell (2009) 139: 231-3.
Category: DNA replication, mitochondria, mitochondrial DNA, mitochondrial nucleoids, protein folding and structure ¤ Added: Oct 29, 2009 ¤ Rating: ◊◊
In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.