Regulatory RNAs: Have mRNA Untranslated Regions Joined the Party?
Hughes PA, Jones PF
PLOS Medicine (2008)
Category: RNA interference ¤ Added: Jun 02, 2008 ¤ Rating: ◊◊
This Perspective discusses the following new study published in PLoS Medicine: Masuda K, Teshima-Kondo S, Mukaijo M, Yamagishi N, Nishikawa Y, et al. (2008) A novel tumor-promoting function residing in the 5’ non-coding region of vascular endothelial growth factor mRNA. PLoS Med 5(5): e94. doi:10.1371/journal. pmed.0050094 Shigetada Teshima-Kondo and colleagues fi nd that cancer cells have a survival system that is regulated by vegf mRNA and that vegf mRNA and its protein may synergistically promote the malignancy of tumor cells.