|Genome instability: a mechanistic view of its causes and consequences.|
Aguilera A, GÃ³mez-GonzÃ¡lez B
Nature Reviews in Genetics (2008)
Category: DNA recombination, DNA repair, DNA replication, telomere ¤ Added: May 26, 2008 ¤ Rating: ◊◊
Genomic instability in the form of mutations and chromosome rearrangements is usually associated with pathological disorders, and yet it is also crucial for evolution. Two types of elements have a key role in instability leading to rearrangements: those that act in trans to prevent instability--among them are replication, repair and S-phase checkpoint factors--and those that act in cis--chromosomal hotspots of instability such as fragile sites and highly transcribed DNA sequences. Taking these elements as a guide, we review the causes and consequences of instability with the aim of providing a mechanistic perspective on the origin of genomic instability.