Anchoring the genome.
Ottaviani D, Lever E, Takousis P, Sheer D
Genome Biology (2008)
Category: chromatin structure, nucleus ¤ Added: Feb 11, 2008 ¤ Rating: ◊◊
ABSTRACT: Although the principles governing chromosomal architecture are largely unresolved, there is evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA sequences to the nuclear matrix. These genome anchors are also crucial regulators of gene expression and DNA replication, and play a role in pathogenesis.