|How stem cells age and why this makes us grow old|
Sharpless NE, DePinho RA
Nature Reviews Molecular Cell Biology (2007)
Category: aging, stem cells ¤ Added: Sep 04, 2007 ¤ Rating: ◊◊
Recent data suggest that we age, in part, because our self-renewing stem cells grow old as a result of heritable intrinsic events, such as DNA damage, as well as extrinsic forces, such as changes in their supporting niches. Mechanisms that suppress the development of cancer, such as senescence and apoptosis, which rely on telomere shortening and the activities of p53 and p16INK4a, may also induce an unwanted consequence: a decline in the replicative function of certain stem-cell types with advancing age. This decreased regenerative capacity appears to contribute to some aspects of mammalian ageing, with new findings pointing to a âstem-cell hypothesisâ for human age-associated conditions such as frailty, atherosclerosis and type 2 diabetes.