A single nucleotide polymorphism in the DNA polymerase gamma gene of Saccharomyces cerevisiae laboratory strains is responsible for increased mitochondrial DNA mutability.
Baruffini E, Lodi T, Dallabona C, Foury F
Genetics (2007)
Category: mitochondria-biogenesis, mitochondrial DNA ¤ Added: Sep 03, 2007 ¤ Rating: ◊◊
In the Saccharomyces cerevisiae strains used for genome sequencing and functional analysis the mitochondrial DNA replicase Mip1p contains a single nucleotide polymorphism changing the strictly conserved threonine 661 to alanine. This substitution is responsible for the increased rate of mitochondrial DNA point mutations and deletions in these strains.