Motoring along with the bacterial RecA protein
Cox MM
Nature Reviews Molecular Cell Biology (2007)
Category: DNA recombination, DNA replication ¤ Added: Jan 24, 2007 ¤ Rating: ◊◊
The recombinases of the RecA family are often viewed only as DNA-pairing proteins — they bind to one DNA segment, align it with homologous sequences in another DNA segment, promote an exchange of DNA strands and then dissociate. To a first approximation, this description seems to fit the eukaryotic (Rad51 and Dmc1) and archaeal (RadA) RecA homologues. However, the bacterial RecA protein does much more, coupling ATP hydrolysis with DNA-strand exchange in a manner that greatly expands its repertoire of activities. This article explores the protein activities and experimental results that have identified RecA as a motor protein.