Protein phosphorylation in plant mitochondria.
Juszczuk IM, Bykova NV, Møller IM
Physiologia Plantarum (2007)
Category: mitochondria-biogenesis, mitochondria-protein phosphorylation ¤ Added: Jan 05, 2007 ¤ Rating: ◊◊
Reversible phosphorylation of proteins is one of the most common regulatory mechanisms in eukaryotic cells and it can affect virtually any property of a protein.We predict that plant mitochondria possess 50–200 protein kinases (PKs), at least as many target proteins and 10–30 protein phosphatases although all will not be expressed at the same time in the same cell type or tissue. Presently available high-throughput methods for the identification of phosphoproteins and their phosphorylation sites are first reviewed and a number of useful databases listed. We then discuss the known phosphoproteins, PKs and phosphatases in plant mitochondria and compare with yeast and mammalian mitochondria. Three case stories—respiratory chain complex I, pyruvate dehydrogenase and formate dehydrogenase—are briefly considered before a final treatment of mitochondrial protein phosphorylation in intracellular signal transduction and programmed cell death.
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