Septins: a ring to part mother and daughter.
Faty M, Fink M, Barral Y
Current Genetics (2002)
Category: cytokinesis ¤ Added: Jun 30, 2002 ¤ Rating: ◊◊
The septins are well conserved GTPases found in animals and fungi. In yeast, they are required for the formation of 10-nm ?laments, with which they co-localize at the bud neck. Therefore, septins have been proposed to be components of the neck ?laments and to have polymerization properties. In support of this hypothesis, septin complexes puri?ed from yeast and ?ies form ?laments in vitro. However, recent studies have questioned the relevance of septin ?lament formation for septin function. Particularly, septin polymerization may not be required for their function in cytokinesis. New septin functions have also been recently uncovered: in budding yeast, the septin ring is required for the maintenance of cell polarity. It forms a cortical barrier that prevents lateral di?usion of membrane-associated proteins through the bud neck. Here, we review the most recent functional and biochemical data, to discuss whether there is a link between septin polymerization properties and septin function.