|Energy biogenesis: one key for coordinating two genomes.|
Sardiello M, Tripoli G, Romito A, Minervini C, Viggiano L, Caggese C, Pesole G
Trends in Genetics (2005)
Category: mitochondria-biogenesis ¤ Added: Sep 28, 2005 ¤ Rating: ◊◊
In metazoan organisms, energy production is the only example of a process that is under dual genetic control: nuclear and mitochondrial. We used a genomic approach to examine how energy genes of both the nuclear and mitochondrial genomes are coordinated, and discovered a novel genetic regulatory circuit in Drosophila melanogaster that is surprisingly simple and parsimonious. This circuit is based on a single DNA regulatory element and can explain both intra- and inter-genomic coordinated expression of genes involved in energy production, including the full complement of mitochondrial and nuclear oxidative phosphorylation genes, and the genes involved in the Krebs cycle.