|Heterotrimeric G Proteins: New Tricks for an Old Dog.|
Hampoelz B, Knoblich JA
Category: cell signaling ¤ Added: Nov 19, 2004 ¤ Rating: ◊◊
Heterotrimeric G proteins are well known for their function in signal transduction downstream of seven transmembrane receptors. More recently, however, genetic analysis in C. elegans and in Drosophila has revealed a second, essential function of these moleby cules in positioning the mitotic spindle and attaching microtubules to the cell cortex. Five new publications in Cell (Afshar et al., 2004; Du and Macara, 2004 [this issue of Cell]; Hess et al., 2004), Developmental Cell (Martin-McCaffrey et al., 2004), and Current Biology (Couwenbergs et al., 2004) show that this function is conserved in vertebrates andlike the classical pathwayinvolves cycling of G proteins between GDP and GTP bound conformations.