Replication fork arrest and DNA recombination.
Michel B
Trends in Biochemical Sciences (2000)
Category: DNA replication ¤ Added: Aug 16, 2004 ¤ Rating: ◊◊
Replication arrests are associated with genome rearrangements, which result from either homologous or non-homologous recombination. Interestingly, proteins involved in homologous recombination are able to convert an arrested replication fork into a recombination intermediate, which promotes replication restart and thus presumably prevents genome rearrangements.