Ion homeostasis in Saccharomyces cerevisiae under NaCl stress.
Wadskog I, Adler L
Topics in Current Genetics (2003)
Category: ion channels, potassium ¤ Added: Jun 02, 2004 ¤ Rating: ◊◊
An essential process associated with salt stress tolerance in S. cerevisiae is the ability to maintain intracellular ion homeostasis. The strategies for the maintenance of a high internal K + /Na + ratio despite high extracellular Na + concentrations involve the concerted action of plasma membrane transport systems as well as intracellular compartmentalization of Na + , mainly in the prevacuole. The present review discusses the systems, which are most critical in determining K + /Na + homeostasis, emphasizing recent progress in our understanding of how cation transport systems are regulated to maintain a functional intracellular ion environment.