TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance.
Ettema TJ, Huynen MA, de Vos WM, van der Oost J
Trends in Biochemical Sciences (2003)
Category: heavy metals ¤ Added: Mar 01, 2004 ¤ Rating: ◊◊
We describe a previously undetected domain - TRASH - containing a well-conserved cysteine motif that we anticipate to be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated.