Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster.
Pletcher SD, MacDonald SJ, Marguerie R, Certa U, Stearns SC, Goldstein DB, Partridge L
Current Biology (2002)
Category: aging ¤ Added: May 02, 2002 ¤ Rating:
We characterized RNA transcript levels for the whole Drosophila genome during normal aging. We compared age-dependent profiles from animals aged under full-nutrient conditions with profiles obtained from animals maintained on a low-calorie medium to determine if caloric restriction slows the aging process. Specific biological functions impacted by caloric restriction were identified using the Gene Ontology annotation. We used the global patterns of expression profiles to test if particular genomic regions contribute differentially to changes in transcript profiles with age and if global disregulation of gene expression occurs during aging.
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