Telomeres, stem cells, senescence, and cancer.
Sharpless NE, DePinho RA
Journal of Clinical Investigation (2004)
Category: telomere ¤ Added: Jan 16, 2004 ¤ Rating: ◊◊
Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16(INK4a)-Rb, ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial antitumor pathways, however, appear also to limit the stem cell life span, thereby contributing to aging.