Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast (MiniReview).
Cheeseman IM, Drubin DG, Barnes G
Journal of Cell Biology (2002)
Category: cell division ¤ Added: Apr 18, 2002 ¤ Rating: ◊◊
Although the budding yeast centromere is extremely short (125 bp) compared to those of other eukaryotes, the kinetochore that assembles on this DNA displays a rich molecular complexity. Here, we describe recent advances in our understanding of kinetochore function in budding yeast and present a model describing the attachment that is formed between spindle microtubules and centromeric DNA. This analysis may provide general principles for kinetochore function and regulation.