Jahn R, Lang T, Sudhof TC
Category: lipids ¤ Added: Feb 25, 2003 ¤ Rating: ◊◊
Membrane fusion, one of the most fundamental pro- cesses in life, occurs when two separate lipid mem- branes merge into a single continuous bilayer. Fusion reactions share common features, but are catalyzed by diverse proteins. These proteins mediate the initial Acrecognition of the membranes that are destined for fusion and pull the membranes close together to de- stabilize the lipid/water interface and to initiate mixing of the lipids. A single fusion protein may do everything or assemblies of protein complexes may be required for intracellular fusion reactions to guarantee rigorous regulation in space and time. Cellular fusion machines macroare adapted to fit the needs of different reactions but hooperate by similar principles in order to achieve merg- ing of the bilayers.