|Mitochondrial Biogenesis in Mammals: The Role of Endogenous Nitric Oxide.|
Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, Bracale R, Valerio A, Francolini M, Moncada S, Carruba MO
Category: mitochondria-biogenesis ¤ Added: Feb 07, 2003 ¤ Rating: ◊◊
Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3,5-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferatoractivated receptor coactivator 1, a master regulator of mitochondrial biogenesis. Moreover, the mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS/) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice. Thus, a nitric oxidecGMPdependent pathway controls mitochondrial biogenesis and body energy balance.