MESSENGER-RNA-BINDING PROTEINS AND THE MESSAGES THEY CARRY.
Dreyfuss G, Kim VN, Kataoka N
Nature Reviews Molecular Cell Biology (2002)
Category: gene expression ¤ Added: Mar 19, 2002 ¤ Rating: ◊◊
From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA processing as well as the transport, localization, translation and stability of mRNAs. Recent discoveries have shown that one group of these proteins marks exon–exon junctions and has a role in mRNA export. These proteins communicate crucial information to the translation machinery for the surveillance of nonsense mutations and for mRNA localization and translation.
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