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Library » authors: Elsea SH
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A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors.
Hsiung Y, Elsea SH, Osheroff N, Nitiss JL
Journal of Biological Chemistry (1995)
Category: topoisomerase ¤ Added: Jul 16th, 2004 ¤ Rating: ◊◊
Increased drug affinity as the mechanistic basis for drug hypersensitivity of a mutant type II topoisomerase.
Froelich-Ammon SJ, Burden DA, Patchan MW, Elsea SH, Thompson RB, Osheroff N
Journal of Biological Chemistry (1995)
Category: topoisomerase ¤ Added: Jul 16th, 2004 ¤ Rating: ◊◊
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
Elsea SH, Hsiung Y, Nitiss JL, Osheroff N
Journal of Biological Chemistry (1995)
Category: topoisomerase ¤ Added: Jul 16th, 2004 ¤ Rating: ◊◊